|Other Accession||NM_018339, NP_060809|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Alias Symbol||FLJ11149, RIFK, RP11-422N19.2|
|Other Names||Riboflavin kinase, 18.104.22.168, ATP:riboflavin 5'-phosphotransferase, Flavokinase, RFK|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RFK antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RFK Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.|
|Tissue Location||Detected in brain, placenta and urinary bladder|
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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Yazdanpanah B.,et al.Nature 460:1159-1163(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Karthikeyan S.,et al.Structure 11:265-273(2003).
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