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TBXAS1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P24557 |
| Other Accession | NM_001061, NP_001052 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61kDa |
| Gene ID | 6916 |
|---|---|
| Alias Symbol | CYP5, CYP5A1, FLJ52771, GHOSAL, THAS, TS, TXAS, TXS, BDPLT14 |
| Other Names | Thromboxane-A synthase, TXA synthase, TXS, 5.3.99.5, Cytochrome P450 5A1, TBXAS1, CYP5, CYP5A1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TBXAS1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TBXAS1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBXAS1 |
|---|---|
| Synonyms | CYP5, CYP5A1 {ECO:0000303|PubMed:1146554 |
| Function | Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation (PubMed:8436233, PubMed:11297515, PubMed:9873013, PubMed:11097184, PubMed:24009185, PubMed:22735388). Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12- HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2 (PubMed:11297515, PubMed:9873013, PubMed:22735388). Additionally, displays dehydratase activity, toward (15S)-hydroperoxy- (5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE (PubMed:17459323). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Yokoyama C.,et al.Biochem. Biophys. Res. Commun. 178:1479-1484(1991).
Ohashi K.,et al.J. Biol. Chem. 267:789-793(1992).
Miyata A.,et al.Eur. J. Biochem. 224:273-279(1994).
Shen R.-F.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Chevalier D.,et al.Mutat. Res. 432:61-67(2001).
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