|Other Accession||NM_173545, NP_775816|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine|
|Alias Symbol||APFL, C2orf13, FLJ16593, MGC47799, PALF, Xip1|
|Other Names||Aprataxin and PNK-like factor, 220.127.116.11, Apurinic-apyrimidinic endonuclease APLF, PNK and APTX-like FHA domain-containing protein, XRCC1-interacting protein 1, APLF, C2orf13, PALF, XIP1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-APLF antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||APLF Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C2orf13, PALF, XIP1|
|Function||Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Kanno S.,et al.EMBO J. 26:2094-2103(2007).
Bekker-Jensen S.,et al.J. Biol. Chem. 282:19638-19643(2007).
Iles N.,et al.Mol. Cell. Biol. 27:3793-3803(2007).
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