|Other Accession||NM_001525, NP_001516|
|Reactivity||Human, Rabbit, Horse|
|Predicted||Human, Rabbit, Horse|
|Other Names||Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R, Hypocretin receptor type 1, HCRTR1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-HCRTR1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HCRTR1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Sakurai T.,et al.Cell 92:573-585(1998).
Peyron C.,et al.Nat. Med. 6:991-997(2000).
Olafsdottir B.R.,et al.Neurology 57:1896-1899(2001).
Yeager M.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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