|Other Names||Hermansky-Pudlak syndrome 6 protein, Ruby-eye protein homolog, Ru, HPS6|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-HPS6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HPS6 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (PubMed:17041891). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning (PubMed:25189619).|
|Cellular Location||Microsome membrane. Cytoplasm, cytosol. Early endosome membrane. Lysosome membrane|
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Provided below are standard protocols that you may find useful for product applications.
Zhang Q.,et al.Nat. Genet. 33:145-153(2003).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Di Pietro S.M.,et al.Traffic 5:276-283(2004).
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