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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPP1CB Antibody - C-terminal region   

PPP1CB Antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - PPP1CB Antibody - C-terminal region AI15279

    WB Suggested Anti-PPP1CB Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Kidney
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62140
Other Accession NM_002709, NP_002700
Reactivity Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Additional Information
Gene ID 5500
Alias Symbol MGC3672, PP-1B, PP1beta, PPP1CD
Other Names Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B, PPP1CD,,, PPP1CB
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-PPP1CB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPPP1CB Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Cellular Location Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles
Research Areas
Citations (0)

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Barker H.M.,et al.Biochim. Biophys. Acta 1220:212-218(1994).
Prochazka M.,et al.Diabetologia 38:461-466(1995).
Verin A.D.,et al.J. Cell. Biochem. 79:113-125(2000).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

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$ 293.00
Cat# AI15279
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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