|Other Accession||NM_005444, NP_005435|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Alias Symbol||CNOT9, CT129, RCD1, RCD1+|
|Other Names||Cell differentiation protein RCD1 homolog, Rcd-1, CCR4-NOT transcription complex subunit 9, RQCD1, CNOT9, RCD1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RQCD1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RQCD1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.|
|Cellular Location||Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body|
|Tissue Location||Detected in spleen, thymus, prostate, testis, ovary and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Okazaki N.,et al.Mol. Cell. Biol. 18:887-895(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (OCT-2009) to UniProtKB.
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