|Other Accession||NM_152753, BAC03798|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||CEGF3, DKFZp686B09105, DKFZp686B1223, DKFZp686D20108, FLJ34743|
|Other Names||Signal peptide, CUB and EGF-like domain-containing protein 3, SCUBE3 (HGNC:13655)|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SCUBE3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SCUBE3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.|
|Cellular Location||Secreted. Cell surface|
|Tissue Location||Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
Wu B.-T.,et al.J. Biol. Chem. 279:37485-37490(2004).
Pfarr N.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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