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THOP1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P52888 |
| Other Accession | NM_003249, NP_003240 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 76kDa |
| Gene ID | 7064 |
|---|---|
| Alias Symbol | EP24.15, MEPD_HUMAN, MP78, TOP |
| Other Names | Thimet oligopeptidase, 3.4.24.15, Endopeptidase 24.15, MP78, THOP1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-THOP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | THOP1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THOP1 |
|---|---|
| Function | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185). Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P47788}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Thompson A.,et al.Biochem. Biophys. Res. Commun. 213:66-73(1995).
Taylor G.R.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Papastoitsis G.,et al.Biochemistry 33:192-199(1994).
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