|Alias Symbol||PRCP, PCP,|
|Other Names||Lysosomal Pro-X carboxypeptidase, 220.127.116.11, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase, PRCP, PRCP, PCP|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-PCP antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PCP Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.|
|Tissue Location||Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Tan F.,et al.J. Biol. Chem. 268:16631-16638(1993).
Tan F.,et al.J. Biol. Chem. 268:26032-26032(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Taylor T.D.,et al.Nature 440:497-500(2006).
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