BCMO1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9HAY6 |
Other Accession | NP_059125 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 60kDa |
Gene ID | 53630 |
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Alias Symbol | BCMO1, BCDO, BCDO1, |
Other Names | Beta, beta-carotene 15, 15'-monooxygenase, 1.14.99.36, Beta-carotene dioxygenase 1, Beta-carotene oxygenase 1 {ECO:0000312|HGNC:HGNC:13815}, BCO1 (HGNC:13815) |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-BCMO1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | BCMO1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCO1 (HGNC:13815) |
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Function | Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9I993} |
Tissue Location | Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
References
Yan W.,et al.Genomics 72:193-202(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Lindqvist A.,et al.J. Nutr. 137:2346-2350(2007).
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