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FBX22 Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - FBX22 Antibody - middle region AI16151

    Host: Rabbit
    Target Name: FBX22
    Sample Tissue: NCI-H226 Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8NEZ5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Additional Information
Gene ID 26263
Alias Symbol FBXO22, FBX22,
Other Names F-box only protein 22, F-box protein FBX22p44, FBXO22, FBX22
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-FBX22 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFBX22 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO22
Synonyms FBX22
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Cellular Location Cytoplasm, myofibril, sarcomere, Z line
Tissue Location Predominantly expressed in liver, also enriched in cardiac muscle.
Research Areas
Citations (0)

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Background

Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

References

Tan P.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Cenciarelli C.,et al.Curr. Biol. 9:1177-1179(1999).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).

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$ 293.00
Cat# AI16151
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