|Application ||WB, IHC|
|Other Accession||NM_000295, NP_000286|
|Alias Symbol||PI, A1A, AAT, PI1, A1AT, PRO2275, alpha1AT|
|Other Names||Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, Short peptide from AAT, SPAAT, SERPINA1, AAT, PI|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 100 ul of distilled water. Final anti-SERPINA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SERPINA1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.|
|Cellular Location||Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum|
|Tissue Location||Ubiquitous. Expressed in leukocytes and plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).
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