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CCNT1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - CCNT1 antibody - N-terminal region AI16181

    Host: Rabbit
    Target Name: CCNT1
    Sample Tissue: Hela
    Antibody Dilution: 1.0μg/mlCCNT1 is supported by BioGPS gene expression data to be expressed in HeLa
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O60563
Other Accession NM_001240, NP_001231
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Neisseria Gonorrhoeae, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Neisseria Gonorrhoeae, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 81kDa
Additional Information
Gene ID 904
Alias Symbol CCNT, CYCT1, HIVE1
Other Names Cyclin-T1, CycT1, Cyclin-T, CCNT1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-CCNT1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsCCNT1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNT1
Function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Background

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.

References

Wei P.,et al.Cell 92:451-462(1998).
Peng J.-M.,et al.Genes Dev. 12:755-762(1998).
Wu X.,et al.Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
Parada C.A.,et al.EMBO J. 18:3688-3701(1999).

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$ 293.00
Cat# AI16181
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