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TFDP1 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - TFDP1 antibody - middle region AI16198

    WB Suggested Anti-TFDP1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: MCF7 cell lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q14186
Other Accession NM_007111, NP_009042
Reactivity Human, Mouse, Bovine
Predicted Human, Mouse, Chicken, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Additional Information
Gene ID 7027
Alias Symbol DP1, DRTF1, Dp-1
Other Names Transcription factor Dp-1, DRTF1-polypeptide 1, DRTF1, E2F dimerization partner 1, TFDP1, DP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-TFDP1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTFDP1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFDP1
Synonyms DP1
Function Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Cellular Location Nucleus.
Tissue Location Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart
Research Areas
Citations (0)

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Background

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.

References

Helin K.,et al.Genes Dev. 7:1850-1861(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bandara L.R.,et al.EMBO J. 13:3104-3114(1994).

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$ 293.00
Cat# AI16198
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