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HTR4 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q13639 |
| Other Accession | NM_000870, NP_000861 |
| Reactivity | Human, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Predicted | Human, Rat, Rabbit, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44kDa |
| Gene ID | 3360 |
|---|---|
| Alias Symbol | 5-HT4, 5-HT4R |
| Other Names | 5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-HTR4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | HTR4 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HTR4 |
|---|---|
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli |
| Tissue Location | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
References
Blondel O.,et al.J. Neurochem. 70:2252-2261(1998).
Van den Wyngaert I.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.NeuroReport 8:3189-3195(1997).
Syversveen T.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.Mol. Pharmacol. 55:910-920(1999).
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