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CHRNA7 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P36544 |
| Other Accession | NM_000746, NP_000737 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Predicted | Human, Mouse, Rat, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56kDa |
| Gene ID | 1139;89832 |
|---|---|
| Alias Symbol | NACHRA7, CHRNA7-2 |
| Other Names | Neuronal acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-CHRNA7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CHRNA7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHRNA7 |
|---|---|
| Synonyms | NACHRA7 |
| Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity) {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:27789755} |
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Provided below are standard protocols that you may find useful for product applications.
Background
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
References
Peng X.,et al.Mol. Pharmacol. 45:546-554(1994).
Logel J.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Elliott K.J.,et al.J. Mol. Neurosci. 7:217-228(1996).
Groot Kormelink P.J.,et al.FEBS Lett. 400:309-314(1997).
Groot Kormelink P.J.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
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