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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   TRIM22 antibody - N-terminal region   

TRIM22 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - TRIM22 antibody - N-terminal region AI16256

    WB Suggested Anti-TRIM22 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Human brain
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8IYM9
Other Accession NM_006074, NP_006065
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Additional Information
Gene ID 10346
Alias Symbol GPSTAF50, RNF94, STAF50
Other Names E3 ubiquitin-protein ligase TRIM22, 6.3.2.-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-TRIM22 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTRIM22 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM22
Synonyms RNF94, STAF50
Function Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Cellular Location Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle- like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies
Tissue Location Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
Research Areas
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Background

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.

References

Tissot C.,et al.J. Biol. Chem. 270:14891-14898(1995).
Reymond A.,et al.EMBO J. 20:2140-2151(2001).
Obad S.,et al.Oncogene 23:4050-4059(2004).
Duan Z.,et al.Biochem. Biophys. Res. Commun. 374:502-506(2008).
Barr S.D.,et al.PLoS Pathog. 4:E1000007-E1000007(2008).

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$ 293.00
Cat# AI16256
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