|Other Accession||NM_145112, NP_660087|
|Reactivity||Human, Mouse, Rat, Dog|
|Predicted||Human, Mouse, Rat, Chicken, Dog|
|Alias Symbol||MGC10775, MGC11225, MGC18164, MGC34679, MGC36767, orf1, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8|
|Other Names||Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X, MAX, BHLHD4|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-MAX antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MAX antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.|
|Cellular Location||Nucleus. Cell projection, dendrite|
|Tissue Location||High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle|
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Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
Blackwood E.M.,et al.Science 251:1211-1217(1991).
Vaestrik I.,et al.Oncogene 8:503-507(1993).
Maekelae T.P.,et al.Science 256:373-377(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
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