|Dilution||IHC-P (6 µg/ml)|
|Other Names||G-protein coupled receptor 3, ACCA orphan receptor, GPR3, ACCA|
|Target/Specificity||Human GPR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SPPL2A (60%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR3 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease|
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Provided below are standard protocols that you may find useful for product applications.
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
Song Z.-H.,et al.Genomics 28:347-349(1995).
Iismaa T.P.,et al.Genomics 24:391-394(1994).
Eggerickx D.,et al.Biochem. J. 309:837-843(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
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