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HTR1B / 5-HT1B Receptor Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - HTR1B / 5-HT1B Receptor Antibody (Internal) ALS10136
    Anti-5HT1B Receptor antibody ALS10136 IHC of human vessel.
  • IHC - HTR1B / 5-HT1B Receptor Antibody (Internal) ALS10136
    Anti-5HT1B Receptor antibody ALS10136 IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P28222
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3351
Other Names 5-hydroxytryptamine receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta receptor, 5-HT-1D-beta, Serotonin receptor 1B, HTR1B, HTR1DB
Target/Specificity Human 5HT1B Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsHTR1B / 5-HT1B Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTR1B
Synonyms HTR1DB
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen
Volume 50 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

References

Hamblin M.W.,et al.Biochem. Biophys. Res. Commun. 184:752-759(1992).
Mochizuki D.,et al.Biochem. Biophys. Res. Commun. 185:517-523(1992).
Jin H.,et al.J. Biol. Chem. 267:5735-5738(1992).
Levy F.O.,et al.J. Biol. Chem. 267:7553-7562(1992).
Weinshank R.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992).

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$ 395.00
Cat# ALS10136
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