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GCGR / Glucagon Receptor Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - GCGR / Glucagon Receptor Antibody (Extracellular Domain) ALS10183
    Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P47871
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 54kDa
Dilution IHC-P (10-20 µg/ml)
Additional Information
Gene ID 2642
Other Names Glucagon receptor, GL-R, GCGR
Target/Specificity Human Glucagon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGCGR / Glucagon Receptor Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCGR
Function G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding
Volume 100 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

References

Macneil D.J.,et al.Biochem. Biophys. Res. Commun. 198:328-334(1994).
Lok S.,et al.Gene 140:203-209(1994).
Menzel S.,et al.Genomics 20:327-328(1994).
Buggy J.J.,et al.Diabetes 46:1400-1405(1997).
Ruckert C.,et al.J. Biol. Chem. 281:2306-2316(2006).

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$ 395.00
Cat# ALS10183
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