|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Horse, Dog|
|Dilution||IHC-P (4 µg/ml)|
|Other Names||Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9, LPAR4, GPR23, LPA4, P2RY9|
|Target/Specificity||Human LPAR4 / GPR23. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||LPAR4 / GPR23 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR23, LPA4, P2RY9|
|Function||Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA.
O'Dowd B.F.,et al.Gene 187:75-81(1997).
Bohm S.K.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
Janssens R.,et al.Biochem. Biophys. Res. Commun. 236:106-112(1997).
Kopatz S.A.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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