|Reactivity||Human, Mouse, Rabbit, Monkey, Pig, Horse, Guinea Pig, Dog|
|Dilution||IHC-P (16 µg/ml)|
|Other Names||Neuropeptide Y receptor type 1, NPY1-R, NPY1R, NPYR, NPYY1|
|Target/Specificity||Human NPY1R. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NPY6R (61%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NPY1R Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Larhammar D.,et al.J. Biol. Chem. 267:10935-10938(1992).
Herzog H.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:5794-5798(1992).
Herzog H.,et al.J. Biol. Chem. 268:6703-6707(1993).
Kopatz S.A.,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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