|Reactivity||Human, Pig, Dog|
|Dilution||IHC-P (11-44 µg/ml)|
|Other Names||C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2|
|Target/Specificity||Human CCR10. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CCR10 / GPR2 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Jarmin D.I.,et al.J. Immunol. 164:3460-3464(2000).
Homey B.,et al.J. Immunol. 164:3465-3470(2000).
Kopatz S.A.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Marchese A.,et al.Genomics 23:609-618(1994).
Wang W.,et al.J. Biol. Chem. 275:22313-22323(2000).
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