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CCKBR / Cckb Antibody (Cytoplasmic Domain)

Rabbit Polyclonal Antibody

     
  • IHC - CCKBR / Cckb Antibody (Cytoplasmic Domain) ALS10323
    Anti-CCKBR / Cckb antibody IHC of human Stomach, Adenocarcinoma.
  • IHC - CCKBR / Cckb Antibody (Cytoplasmic Domain) ALS10323
    Anti-CCKBR antibody ALS10323 IHC of human stomach.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P32239
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution IHC-P (3 µg/ml)
Additional Information
Gene ID 887
Other Names Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB
Target/Specificity Human CCKBR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCCKBR / Cckb Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCKBR
Synonyms CCKRB
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

References

Pisegna J.R.,et al.Biochem. Biophys. Res. Commun. 189:296-303(1992).
Lee Y.-M.,et al.J. Biol. Chem. 268:8164-8169(1993).
Ito M.,et al.J. Biol. Chem. 268:18300-18305(1993).
Song I.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:9085-9089(1993).
Herget T.,et al.Ann. N. Y. Acad. Sci. 713:283-297(1994).

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$ 395.00
Cat# ALS10323
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