|Dilution||IHC-P (2-5 µg/ml)|
|Other Names||Proteinase-activated receptor 4, PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3, F2RL3, PAR4|
|Target/Specificity||Human F2RL3 / PAR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||F2RL3 / PAR4 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Kahn M.L.,et al.J. Biol. Chem. 273:23290-23296(1998).
Kahn M.L.,et al.Nature 394:690-694(1998).
Xu W.-F.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:6642-6646(1998).
King M.M.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Kahn M.L.,et al.J. Clin. Invest. 103:879-887(1999).
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