|Application ||IHC-P, E|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3|
|Target/Specificity||Human CCR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CCR3 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||In eosinophils as well as trace amounts in neutrophils and monocytes|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Combadiere C.,et al.J. Biol. Chem. 270:16491-16494(1995).
Combadiere C.,et al.J. Biol. Chem. 270:30235-30235(1995).
Daugherty B.L.,et al.J. Exp. Med. 183:2349-2354(1996).
Ponath P.D.,et al.J. Exp. Med. 183:2437-2448(1996).
Xiao L.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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