|Reactivity||Human, Mouse, Monkey, Pig, Bovine|
|Dilution||IHC-P (11 µg/ml)|
|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, 3.4.24.-, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS5, ADAMTS11, ADMP2|
|Target/Specificity||Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||ADAMTS5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient|
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Provided below are standard protocols that you may find useful for product applications.
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
Abbaszade I.,et al.J. Biol. Chem. 274:23443-23450(1999).
Hattori M.,et al.Nature 405:311-319(2000).
Hurskainen T.L.,et al.J. Biol. Chem. 274:25555-25563(1999).
Wang L.W.,et al.J. Biol. Chem. 284:30004-30015(2009).
Mosyak L.,et al.Protein Sci. 17:16-21(2008).
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