|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Bovine, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR, SLC-1, Somatostatin receptor-like protein, MCHR1, GPR24, SLC1|
|Target/Specificity||Human MCHR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||MCHR1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Shimomura Y.,et al.Biochem. Biophys. Res. Commun. 261:622-626(1999).
Wermter A.-K.,et al.Eur. J. Endocrinol. 152:851-862(2005).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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