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FFAR1 / GPR40 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - FFAR1 / GPR40 Antibody (C-Terminus) ALS10411
    Anti-GPR40 antibody ALS10411 IHC of human brain, neurons.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O14842
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Dilution IHC-P (9-18 µg/ml)
Additional Information
Gene ID 2864
Other Names Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40
Target/Specificity Human GPR40. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsFFAR1 / GPR40 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FFAR1
Synonyms GPR40
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and pancreas. Detected in pancreatic beta cells.
Volume 50 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

References

Sawzdargo M.,et al.Biochem. Biophys. Res. Commun. 239:543-547(1997).
Briscoe C.P.,et al.J. Biol. Chem. 278:11303-11311(2003).
Tomita T.,et al.Biochem. Biophys. Res. Commun. 338:1788-1790(2005).
Sum C.S.,et al.J. Biol. Chem. 282:29248-29255(2007).
Sum C.S.,et al.J. Biol. Chem. 284:3529-3536(2009).

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$ 395.00
Cat# ALS10411
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