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TAAR1 / TA1 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - TAAR1 / TA1 Antibody (Extracellular Domain) ALS10500
    Anti-TAAR1 antibody ALS10500 IHC of human brain, neurons.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q96RJ0
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Dilution IHC-P (6-15 µg/ml)
Additional Information
Gene ID 134864
Other Names Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1, TAAR1, TA1, TAR1, TRAR1
Target/Specificity Human TAAR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsTAAR1 / TA1 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAAR1
Synonyms TA1, TAR1, TRAR1
Function Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues. Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

References

Borowsky B.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
Bunzow J.R.,et al.Mol. Pharmacol. 60:1181-1188(2001).
Kopatz S.A.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Lindemann L.,et al.Genomics 85:372-385(2005).

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$ 395.00
Cat# ALS10500
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