|Dilution||IHC-P (10-20 µg/ml)|
|Other Names||Leukotriene B4 receptor 2, LTB4-R 2, LTB4-R2, LTB4 receptor JULF2, Leukotriene B4 receptor BLT2, Seven transmembrane receptor BLTR2, LTB4R2, BLT2R, BLTR2|
|Target/Specificity||Human LTB4R2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PPM2C (47%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||LTB4R2 / BLT2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
Tryselius Y.,et al.Biochem. Biophys. Res. Commun. 274:377-382(2000).
Yokomizo T.,et al.J. Exp. Med. 192:421-432(2000).
Hirose M.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Volpe F.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Kopatz S.A.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
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