|Reactivity||Human, Rabbit, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||IHC-P (1 µg/ml)|
|Other Names||5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4|
|Target/Specificity||Human 5HT4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.|
|Tissue Location||Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Blondel O.,et al.J. Neurochem. 70:2252-2261(1998).
Van den Wyngaert I.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.NeuroReport 8:3189-3195(1997).
Syversveen T.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.Mol. Pharmacol. 55:910-920(1999).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.