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MRGX1 / MRGPRX1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - MRGX1 / MRGPRX1 Antibody (N-Terminus) ALS10582
    Anti-MRGPRX1 / MRGX1 antibody ALS10582 IHC of human ganglion cells and Schwann cells.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC
Primary Accession Q96LB2
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 36kDa
Dilution IHC-P (12 µg/ml)
Additional Information
Gene ID 259249
Other Names Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4, MRGPRX1, MRGX1, SNSR3, SNSR4
Target/Specificity Human MRGPRX1 / MRGX1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MRGPRX3 (71%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsMRGX1 / MRGPRX1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRGPRX1
Synonyms MRGX1, SNSR3, SNSR4
Function Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons
Volume 50 µl
Research Areas
Citations (0)

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Background

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner.

References

Dong X.,et al.Cell 106:619-632(2001).
Lembo P.M.C.,et al.Nat. Neurosci. 5:201-209(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS10582
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