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MRGX1 / MRGPRX1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, ICC |
|---|---|
| Primary Accession | Q96LB2 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36kDa |
| Dilution | IHC-P (12 µg/ml) |
| Gene ID | 259249 |
|---|---|
| Other Names | Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4, MRGPRX1, MRGX1, SNSR3, SNSR4 |
| Target/Specificity | Human MRGPRX1 / MRGX1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MRGPRX3 (71%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | MRGX1 / MRGPRX1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MRGPRX1 |
|---|---|
| Synonyms | MRGX1, SNSR3, SNSR4 |
| Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine- independent manner. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner.
References
Dong X.,et al.Cell 106:619-632(2001).
Lembo P.M.C.,et al.Nat. Neurosci. 5:201-209(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Taylor T.D.,et al.Nature 440:497-500(2006).
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