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SLC5A11 / SMIT2 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - SLC5A11 / SMIT2 Antibody (Extracellular Domain) ALS10589
    Anti-SLC5A11 antibody ALS10589 IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8WWX8
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 74kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 115584
Other Names Sodium/myo-inositol cotransporter 2, Na(+)/myo-inositol cotransporter 2, Sodium-dependent glucose cotransporter, Sodium/glucose cotransporter KST1, Sodium/myo-inositol transporter 2, SMIT2, Solute carrier family 5 member 11, SLC5A11 {ECO:0000312|EMBL:EAW55781.1}
Target/Specificity Human SLC5A11. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SLC5A2 (65%), SLC5A9 (65%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsSLC5A11 / SMIT2 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC5A11 {ECO:0000312|EMBL:EAW55781.1}
Function Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
Cellular Location Membrane {ECO:0000250|UniProtKB:Q28728}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q28728}
Tissue Location Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes
Research Areas
Citations (0)

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Background

Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

References

Roll P.,et al.Gene 285:141-148(2002).
Mount D.B.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Bruss M.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).

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$ 395.00
Cat# ALS10589
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