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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SPHK / SPHK1 Antibody (N-Terminus)   

SPHK / SPHK1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SPHK / SPHK1 Antibody (N-Terminus) ALS10625
    Anti-SPHK1 antibody ALS10625 IHC of human adrenal, pheochromocytes.
  • SPECIFICATION
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9NYA1
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 8877
Other Names Sphingosine kinase 1, SK 1, SPK 1, 2.7.1.91, SPHK1, SPHK, SPK
Target/Specificity Human SPHK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsSPHK / SPHK1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPHK1
Synonyms SPHK, SPK
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
Cellular Location Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner
Tissue Location Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle
Volume 50 µl
Research Areas
Citations (0)

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Background

Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.

References

Melendez A.J.,et al.Gene 251:19-26(2000).
Nava V.E.,et al.FEBS Lett. 473:81-84(2000).
Pitson S.M.,et al.Biochem. J. 350:429-441(2000).
Van Veldhoven P.P.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS10625
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