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NPSR1 / NPSR / GPR154 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - NPSR1 / NPSR / GPR154 Antibody (Extracellular Domain) ALS10632
    Anti-NPSR1 antibody ALS10632 IHC of human testis.
  • IHC - NPSR1 / NPSR / GPR154 Antibody (Extracellular Domain) ALS10632
    Anti-NPSR1 antibody ALS10632 IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q6W5P4
Reactivity Human, Mouse, Hamster, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 387129
Other Names Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility, NPSR1, GPR154, GPRA, PGR14
Target/Specificity Human NPSR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsNPSR1 / NPSR / GPR154 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPSR1
Synonyms GPR154, GPRA, PGR14
Function G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.
Cellular Location Isoform 1: Cell membrane; Multi- pass membrane protein Isoform 4: Cell membrane; Multi-pass membrane protein Isoform 5: Cytoplasm Isoform 7: Cytoplasm
Tissue Location Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients
Volume 50 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.

References

Laitinen T.,et al.Science 304:300-304(2004).
Vendelin J.,et al.Am. J. Respir. Cell Mol. Biol. 33:262-270(2005).
Uebele V.N.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS10632
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