|Reactivity||Human, Mouse, Hamster, Monkey|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility, NPSR1, GPR154, GPRA, PGR14|
|Target/Specificity||Human NPSR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NPSR1 / NPSR / GPR154 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR154, GPRA, PGR14|
|Function||G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.|
|Cellular Location||Isoform 1: Cell membrane; Multi- pass membrane protein Isoform 4: Cell membrane; Multi-pass membrane protein Isoform 5: Cytoplasm Isoform 7: Cytoplasm|
|Tissue Location||Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients|
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G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.
Laitinen T.,et al.Science 304:300-304(2004).
Vendelin J.,et al.Am. J. Respir. Cell Mol. Biol. 33:262-270(2005).
Uebele V.N.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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