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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Ceramide Kinase / CERK Antibody (N-Terminus)   

Ceramide Kinase / CERK Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - Ceramide Kinase / CERK Antibody (N-Terminus) ALS10651
    Anti-CERK antibody ALS10651 IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8TCT0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 60kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 64781
Other Names Ceramide kinase, hCERK, 2.7.1.138, Acylsphingosine kinase, Lipid kinase 4, LK4, CERK, KIAA1646
Target/Specificity Human CERK. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCeramide Kinase / CERK Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CERK
Synonyms KIAA1646
Function Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung
Volume 50 µl
Research Areas
Citations (0)

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Background

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

References

Sugiura M.,et al.J. Biol. Chem. 277:23294-23300(2002).
Van Veldhoven P.P.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).

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$ 395.00
Cat# ALS10651
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