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FSD2 / Frizzled 2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - FSD2 / Frizzled 2 Antibody (N-Terminus) ALS10670
    Anti-FSD2 / Frizzled 2 antibody IHC of human Brain, Glioblastoma.
  • IHC - FSD2 / Frizzled 2 Antibody (N-Terminus) ALS10670
    Anti-Frizzled 2 antibody ALS10670 IHC of human fetal kidney.
  • IHC - FSD2 / Frizzled 2 Antibody (N-Terminus) ALS10670
    Anti-FSD2 / Frizzled 2 antibody IHC of human Ovary, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q14332
Reactivity Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 64kDa
Dilution IHC-P (8 µg/ml)
Additional Information
Gene ID 2535
Other Names Frizzled-2, Fz-2, hFz2, FzE2, FZD2
Target/Specificity Human Frizzled 2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD7 (60%), DMAP1 (40%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsFSD2 / Frizzled 2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD2
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

References

Zhao Z.,et al.Genomics 27:370-373(1995).
Sagara N.,et al.Biochem. Biophys. Res. Commun. 252:117-122(1998).
Tanaka S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998).

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$ 395.00
Cat# ALS10670
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