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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GPR44 / CRTH2 Antibody (Extracellular Domain)   

GPR44 / CRTH2 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - GPR44 / CRTH2 Antibody (Extracellular Domain) ALS10673
    Anti-GPR44 / CRTH2 antibody ALS10673 IHC of human tonsil.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9Y5Y4
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (2.5-5 µg/ml)
Additional Information
Gene ID 11251
Other Names Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, CD294, PTGDR2, CRTH2, DL1R, GPR44
Target/Specificity Human GPR44 / CRTH2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR44 / CRTH2 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTGDR2
Synonyms CRTH2, DL1R, GPR44
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Internalized receptors colocalized with RAB11A.
Tissue Location Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.

References

Marchese A.,et al.Genomics 56:12-21(1999).
Nagata K.,et al.J. Immunol. 162:1278-1286(1999).
Methner A.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS10673
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(40 western blots)
Availability: 5 days
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