|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Rabbit, Hamster, Monkey, Bovine, Guinea Pig, Dog|
|Dilution||IHC-P (2-5 µg/ml)|
|Other Names||P2Y purinoceptor 1, P2Y1, ATP receptor, Purinergic receptor, P2RY1|
|Target/Specificity||Human P2RY1 / P2Y1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||P2RY1 / P2Y1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
Leon C.,et al.Gene 171:295-297(1996).
Ayyanathan K.,et al.Biochem. Biophys. Res. Commun. 218:783-788(1996).
Janssens R.,et al.Biochem. Biophys. Res. Commun. 221:588-593(1996).
Leon C.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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