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EAR2 / NR2F6 Antibody (Ligand-binding Domain)

Rabbit Polyclonal Antibody

     
  • IHC - EAR2 / NR2F6 Antibody (Ligand-binding Domain) ALS10829
    Anti-EAR2 / NR2F6 antibody IHC of human Skin, Melanoma.
    detail
  • IHC - EAR2 / NR2F6 Antibody (Ligand-binding Domain) ALS10829
    Anti-EAR2 / NR2F6 antibody IHC of human Breast, Carcinoma.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P10588
Reactivity Human, Mouse, Zebrafish, Hamster, Monkey, Pig, Xenopus, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 2063
Other Names Nuclear receptor subfamily 2 group F member 6, V-erbA-related protein 2, EAR-2, NR2F6, EAR2, ERBAL2
Target/Specificity Human NR2F6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsEAR2 / NR2F6 Antibody (Ligand-binding Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2F6
Synonyms EAR2, ERBAL2
Function Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:18701084}
Tissue Location Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.
Volume 50 µl
Citations (0)
citation

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Background

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

References

Miyajima N.,et al.Nucleic Acids Res. 16:11057-11074(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Y.,et al.J. Biol. Chem. 275:2763-2770(2000).
Zhu X.G.,et al.Mol. Cell. Biol. 20:2604-2618(2000).

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Discontinued
Cat# ALS10829
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