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RARB / RAR Beta Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - RARB / RAR Beta Antibody (C-Terminus) ALS10833
    Anti-RARB antibody ALS10833 IHC of human intermediate trophoblasts.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P10826
Reactivity Human, Monkey, Pig, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 5915
Other Names Retinoic acid receptor beta, RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon, RARB, HAP, NR1B2
Target/Specificity Human RARB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsRARB / RAR Beta Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RARB
Synonyms HAP, NR1B2
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Cellular Location Isoform Beta-1: Nucleus. Isoform Beta-4: Cytoplasm.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

References

Benbrook D.,et al.Nature 333:669-672(1988).
de The H.,et al.Nature 330:667-670(1987).
Sommer K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:8651-8656(1999).
Shen S.,et al.DNA Seq. 2:111-119(1991).
Houle B.,et al.Cancer Res. 54:365-369(1994).

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$ 395.00
Cat# ALS10833
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