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CRFR1 / CRHR1 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - CRFR1 / CRHR1 Antibody (Extracellular Domain) ALS10852
    Anti-CRF1 antibody ALS10852 IHC of human pituitary.
  • IHC - CRFR1 / CRHR1 Antibody (Extracellular Domain) ALS10852
    Anti-CRFR1 / CRHR1 antibody IHC of human brain, putamen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P34998
Reactivity Human, Hamster, Monkey, Pig, Sheep, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 51kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 104909134;1394
Other Names Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1, CRFR, CRFR1, CRHR
Target/Specificity Human CRF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCRFR1 / CRHR1 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRHR1
Synonyms CRFR, CRFR1, CRHR
Function G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis
Tissue Location Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe
Volume 50 µl
Research Areas
Citations (0)

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Background

G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

References

Chen R.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:8967-8971(1993).
Vita N.,et al.FEBS Lett. 335:1-5(1993).
Sakai K.,et al.Gene 219:125-130(1998).
Ross P.C.,et al.Biochem. Biophys. Res. Commun. 205:1836-1842(1994).
Grammatopoulos D.K.,et al.Mol. Endocrinol. 13:2189-2202(1999).

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$ 395.00
Cat# ALS10852
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