|Reactivity||Human, Rabbit, Hamster, Monkey, Pig, Horse, Xenopus, Bovine, Dog|
|Dilution||IHC-P (34 µg/ml)|
|Other Names||Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR|
|Target/Specificity||Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CALCR (56%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CALCRL / CGRP Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in the lung and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Aiyar N.,et al.J. Biol. Chem. 271:11325-11329(1996).
Fluehmann B.,et al.Biochem. Biophys. Res. Commun. 206:341-347(1995).
Kopatz S.A.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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