NEK9 Antibody (Kinase Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IHC-P |
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Primary Accession | Q8TD19 |
Reactivity | Human, Mouse, Rabbit, Monkey, Pig, Chicken, Horse, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 107kDa |
Dilution | IHC-P (4 µg/ml) |
Gene ID | 91754 |
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Other Names | Serine/threonine-protein kinase Nek9, 2.7.11.1, Nercc1 kinase, Never in mitosis A-related kinase 9, NimA-related protein kinase 9, NimA-related kinase 8, Nek8, NEK9, KIAA1995, NEK8, NERCC |
Target/Specificity | Human NEK9. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | NEK9 Antibody (Kinase Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NEK9 {ECO:0000303|PubMed:12840024, ECO:0000312|HGNC:HGNC:18591} |
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Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts |
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Background
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
References
Holland P.M.,et al.J. Biol. Chem. 277:16229-16240(2002).
Roig J.,et al.Genes Dev. 16:1640-1658(2002).
Ohara O.,et al.DNA Res. 9:47-57(2002).
Heilig R.,et al.Nature 421:601-607(2003).
Belham C.,et al.J. Biol. Chem. 278:34897-34909(2003).
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