ERP44 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q9BS26 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47kDa |
Dilution | IHC-P (15-20 µg/ml) |
Gene ID | 23071 |
---|---|
Other Names | Endoplasmic reticulum resident protein 44, ER protein 44, ERp44, Thioredoxin domain-containing protein 4, ERP44, KIAA0573, TXNDC4 |
Target/Specificity | Human ERP44 / TXNDC4. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | ERP44 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ERP44 |
---|---|
Synonyms | KIAA0573, TXNDC4 |
Function | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230, PubMed:14517240). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). |
Cellular Location | Endoplasmic reticulum lumen |
Volume | 62.5 µl |
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Background
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.
References
Anelli T.,et al.EMBO J. 21:835-844(2002).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
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