EMB/ Embigin Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q6PCB8 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37kDa |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 133418 |
---|---|
Other Names | Embigin, EMB |
Target/Specificity | Human EMB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RALGPS1 (53%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | EMB/ Embigin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EMB |
---|---|
Function | Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:O88775}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O88775} Synapse {ECO:0000250|UniProtKB:P21995}. Note=Localizes to the neuromuscular junctions. {ECO:0000250|UniProtKB:P21995} |
Volume | 50 µl |
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Background
Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Wollscheid B.,et al.Nat. Biotechnol. 27:378-386(2009).
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