|Reactivity||Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||IHC-P (5-10 µg/ml)|
|Other Names||Solute carrier family 12 member 2, Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, SLC12A2, NKCC1|
|Target/Specificity||Human SLC12A2 / NKCC1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CDR2 (41%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||SLC12A2 / NKCC1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in many tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Payne J.A.,et al.J. Biol. Chem. 270:17977-17985(1995).
Vibat C.R.,et al.Anal. Biochem. 298:218-230(2001).
Cantin G.T.,et al.J. Proteome Res. 7:1346-1351(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cruz-Rangel S.,et al.Am. J. Physiol. 301:C601-C608(2011).
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